Corso di Laurea in Biotecnologie

Dynamics and Toxicology

Dynamics and Toxicology

Anno accademico 2023/2024

• GENERAL PHARMACOLOGY AND TOXICOLOGY (BIO0173)

Sommario insegnamento

• Obiettivi formativi
• Risultati dell'apprendimento attesi
• Modalità di insegnamento
• Modalità di verifica dell'apprendimento
• Programma
• Testi consigliati e bibliografia
• Strumenti didattici

Obiettivi formativi

Pharmacology
Learning the general principles of pharmacodynamics and the analysis of the main transmission systems.

Toxicology
The course aims to provide students with knowledge of the basic principles of toxicology and the mechanisms of toxic action of xenobiotics.

Risultati dell'apprendimento attesi

Pharmacology
At the end of the course the student acquires the fundamental mechanisms that regulate cellular pharmacology,the main factors responsible for variability in drug response and   the mecchanism of action of drugs active on the main neurotransmission systems.

Toxicology
At the end of the course the student acquires knowledge useful for the integrated understanding of the phenomena at biochemical, cellular, molecular, pathophysiological level that underlie the toxicity of a drug or a xenobiotic one; it includes the ways in which a toxic person can come into contact with biological material, the effects of certain organs and systems following exposure, as a cause of both acute and chronic diseases. It also achieves a scientific preparation useful for dealing with issues related to the risk assessment from exposure to chemical agents.

Modalità di insegnamento

The Pharmacology module of Prof. Eva C. and Dott. Bertocchi I. (4CFU) consists of 32 hours.
The Toxicology module of Prof. De Francia S. (2CFU) consists of 16 hours.

The course is taught in English through frontal lesson. Given the current pandemic situation, the remote mode (Webex or Big Blu ButtonBN) is ensured throughout the academic year. Students for this purpose will receive a webex meeting invitation via email, or they will find the Big Blu ButtonBN activity for the connection on Moodle.

Modalità di verifica dell'apprendimento

The exam will be in written form with an open question for each parts. Students have 60 minutes to complete the test.

The final mark is given by the weighted average with respect to the credits of each parts.

The learning verification methods may vary according to the limitations imposed by the current health crisis. In any case, the remote mode is guaranteed for the entire academic year.

Programma

Pharmacology program

Dr. Bertocchi I.

Generality
Cellular and molecular pharmacology

Drug-receptor interaction
Study of the action of agonist and antagonist drugs
Main targets of the action of a drug

Eva C.

Pharmacology of the main neurotransmission systems.

Toxicology program

Prof. De Francia S.

Principles of general toxicology: definitions and aims of Toxicology, bases for the general classification of a toxic effect.
Chiral compounds. Distomer and eutomer. Racemic mixtures.
Toxicology of solids. Elements characterizing the toxicity of solids.
Mechanisms of cell damage. Analysis of some of the investigative tools available to the toxicologist.
Cell death: apoptosis and necrosis; morphological, biochemical and molecular aspects. Test to ascertain apoptosis.
Genotoxicity: main mutational events and their pathological consequences, genotoxicity test.
Carcinogenesis: characteristics of the carcinogenic process, classification of carcinogens (initiators, promoters, co-carcinogens, genotoxic carcinogens). Carcinogenicity test.
Biomarkers. Assessment of the toxicological risk and the safety of use of drugs and xenobiotics.
Toxic responses of the central nervous system: organization of the central nervous system, classification of neurotoxic effects, neurotoxins.
Toxic responses of the reproductive cycle: principles of developmental toxicity, nature of toxic effects and mechanisms of action.
Doping. Elements of sex and gender toxicology

Teaching material provided by the professor.

TOSSICOLOGIA MOLECOLARE E CELLULARE, Giorgio Cantelli Forti, Corrado L. Galli, Patrizia Hrelia       (UTET)
ELEMENTI DI TOSSICOLOGIA, Casarett & Doull - ( a cura di Hrelia P e Cantelli Forti G), Casa Editrice Ambrosiana, Milano, 2013

FARMACOLOGIA MOLECOLARE E CELLULARE,  Paoletti R, Nicosia S, Clementi F, Fumagalli G, Utet 

FARMACOLOGIA Principi di base e applicazioni terapeutiche - Francesco Rossi, Vincenzo Cuomo, Carlo Riccardi et al.  Minerva Medica

• Materiale didattico
• Bacheca appelli
• Vai a Moodle
• Visita i forum