Corso di Laurea in Biotecnologie

IMMUNOLOGIA MOLECOLARE

Anno accademico 2011/2012

Sommario insegnamento

• Programma
• Testi consigliati e bibliografia
• Strumenti didattici

Programma

Structure of antibodies: What are antibodies?, Ig variable domain, Ig constant domain

Classes of Immunoglobulins: IgG, IgA, IgD, IgM, IgE

Biological function of antibodies: Direct activity of antibodies, Neutralization, Formation of immune complexes

Indirect activity of antibodies: Complement activation, Opsonization, Activation of cell functions through Fc receptors

The Fc region: Molecular structure, Cellular expression, Functions. Activating-type of FcR: Role of ITIM sequences, Inhibitory FcR: Role of ITAM motifs

Responses mediated by FcR: ADCC (NK), Degranulation of mast cell / basophils / eosinophils, Endocytosis, Phagocytosis, Release of inflammatory mediators, Regulation of B cells activation

FcR for IgG: FcGammaRI (or CD64), structure and function, FcGammaRII-A, FcGammaRII-B2, FcGammaRII-B1 (or CD32), structure and function, FcGammaRIII (or CD16), structure and function

FcR for IgG: FcGammaRII-B1 and the phagocytosis of immune complexes, FcGammaRII-B2 and the clathrin-mediated endocytosis, FcGammaRIII and ADCC, FcRn

FcR for IgE: FcEpsilonRI receptor, structure and function, FcEpsilonRI activating function, FcEpsilonRII receptor (or CD23), structure and function

FcR for IgA: FcAlphaRI (or CD89), structure and function, The poly-Ig-R, The FcAlpha/MiR, Two “alternative” IgA receptors: the asialoglycoprotein receptor and the transferrin receptor, IgA receptors in health and disease

Recombinant antibodies made with fragments of the Ig: The Fc region of therapeutic antibodies, Structure of recombinant Abs, Action of recombinant Abs

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