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IMMUNOLOGIA MOLECOLARE
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MOLECULAR IMMUNOLOGY
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Anno accademico 2013/2014
- Codice dell'attività didattica
- INT0657
- Docente
- Prof. Federica CAVALLO (Titolare del corso)
- Corso di studi
- laurea spec. in biotecnologie molecolari ed Indirizzo Imaging
- Anno
- 1° anno
- Periodo didattico
- Secondo semestre
- Tipologia
- Caratterizzante
- Crediti/Valenza
- 5
- SSD dell'attività didattica
- MED/04 - patologia generale
- Modalità di erogazione
- Tradizionale
- Lingua di insegnamento
- Inglese
- Modalità di frequenza
- Obbligatoria
- Tipologia d'esame
- Scritto ed orale
- Prerequisiti
- Conoscenza dell'Immunologia di base (III Anno - I Livello)
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Sommario insegnamento
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Obiettivi formativi
To provide an advanced biotechnological up-dating about Macrophages, their receptors, their actions.- Oggetto:
Risultati dell'apprendimento attesi
To teach how to prepare and present a scientific concept.- Oggetto:
Programma
Origin and Morphology of Macrophages: Maturation and function;Chemokines: regulators of development, trafficking and functions; Organ-specific features; Tissue distribution; Education Activation and Programming
Macrophage Subsets: Classically activated Macrophages (M1), Alternatively Activated Macrophages (M2), “Regulatory” Macrophages (IL-10 secretion), Tumor-associated Macrophages (TAMs), Myeloid Derived Suppressor Cells (MDSCs), Lymph node (LN) macrophages, Plasticity and Polarization, Imaging of Macrophages
Function of Macrophages: Phagocytosis: Scavenger Receptors and Toll-like Receptors; Cytokine secretion; Antigen presentation; Homeostatic functions in tissues; Other functions: Iron Trafficking and Metabolism
Functions of Macrophages in Innate Immunity: The phagocytosis process, Role in antimicrobial immunity, Tissue repair
Functions of Macrophages in Adaptive Immunity: Control of T cell proliferation, Interaction with T reg cells, Immunosuppression, Alternative activation of Macrophages
Macrophages and Pregnancy: Monocyte/Macrophages in human pregnancy, Pregnancy Immunology: Decidual Macrophages and their Roles, Role of Macrophages in Utero-placental Interactions
Macrophages and Diseases: Role of macrophages in different diseases, Adipose tissue Macrophages in metabolic disorders, M2 in allergy and asthma, Macrophage subsets and autoimmunity, Macrophages and atherosclerosis, Macrophages in pathogenesis of fibrosis
Macrophages and Tumors: Role of macrophages in tumorigenesis and tumor progression, Macrophages and cancer: balance, tolerance, and diversity, Macrophages in Tumor Microenvironments, Macrophages and Tumor Suppressors
Imaging of Macrophages: Imaging techniques for evaluating cells activation, Tracking immune cells using MRI, Monocytes/Macrophages as nanomedicinal targets
Testi consigliati e bibliografia
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Ivan K. H. Poon, Christopher D. Lucas, Adriano G. Rossi & Kodi S. Ravichandran. Apoptotic cell clearance: basic biology and therapeutic potential. Nature Reviews Immunology 14, 166-180 doi:10.1038/nri3607
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Ahrens Eric T. and Jeff W. M. Bulte. Tracking immune cells in vivo using magnetic resonance imaging. Nat Rev Immunol. 2013 October; 13(10): 10.1038/nri3531.
- Chiba T, Umegaki K. Pivotal roles of monocytes/macrophages in stroke. Mediators Inflamm. 2013;2013:759103.
- Davignon JL, Hayder M, Baron M, Boyer JF, Constantin A, Apparailly F, Poupot R, Cantagrel A. Targeting monocytes/macrophages in the treatment of rheumatoid arthritis. Rheumatology (Oxford). 2013 Apr;52(4):590-8.
- Filip K. Swirski, Matthias Nahrendorf. Imaging Macrophage Development and Fate in Atherosclerosis and Myocardial Infarction. Immunol Cell Biol. Author manuscript; available in PMC 2013 December 30.
- Jain NK, Mishra V, Mehra NK. Targeted drug delivery to macrophages. Expert Opin Drug Deliv. 2013 Mar;10(3):353-67.
- Liu G, Yang H. Modulation of macrophage activation and programming in immunity. J Cell Physiol. 2013 Mar;228(3):502-12.
- Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol. 2013 Jan;229(2):176-85.
- Moore KJ, Sheedy FJ, Fisher EA. Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol. 2013 Oct;13(10):709-21.
- Shechter R, London A, Schwartz M. Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates. Nat Rev Immunol. 2013 Mar;13(3):206-18.
- Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013 Apr 25;496(7446):445-55.
- Brown BN, Ratner BD, Goodman SB, Amar S, Badylak SF. Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials. 2012 May;33(15):3792-802.
- Byeon SE, Yi YS, Oh J, Yoo BC, Hong S, Cho JY. The role of Src kinase in macrophage-mediated inflammatory responses. Mediators Inflamm. 2012;2012:512926.
- Byrne JC, Ní Gabhann J, Lazzari E, Mahony R, Smith S, Stacey K, Wynne C, Jefferies CA. Genetics of SLE: functional relevance for monocytes/macrophages in disease. Clin Dev Immunol. 2012;2012:582352.
- Gray EE, Cyster JG. Lymph node macrophages. J Innate Immun. 2012;4(5-6):424-36.
- Hao NB, Lü MH, Fan YH, Cao YL, Zhang ZR, Yang SM. Macrophages in tumor microenvironments and the progression of tumors. Clin Dev Immunol. 2012;2012:948098.
- Houser BL. Decidual macrophages and their roles at the maternal-fetal interface. Yale J Biol Med. 2012 Mar;85(1):105-18.
- Hutchinson JA, Riquelme P, Geissler EK. Human regulatory macrophages as a cell-based medicinal product. Curr Opin Organ Transplant. 2012 Feb;17(1):48-54.
- Koppensteiner H, Brack-Werner R, Schindler M. Macrophages and their relevance in Human Immunodeficiency Virus Type I infection. Retrovirology. 2012 Oct 4;9:82.
- Ramakrishnan L. Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol. 2012 Apr 20;12(5):352-66.
- Schmieder A, Michel J, Schönhaar K, Goerdt S, Schledzewski K. Differentiation and gene expression profile of tumor-associated macrophages. Semin Cancer Biol. 2012 Aug;22(4):289-97.
- Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012 Mar 1;122(3):787-95.
- Siddiqui R, Khan NA. Acanthamoeba is an evolutionary ancestor of macrophages: a myth or reality? Exp Parasitol. 2012 Feb;130(2):95-7.
- Través PG, Luque A, Hortelano S. Macrophages, inflammation, and tumor suppressors: ARF, a new player in the game. Mediators Inflamm. 2012;2012:568783.
- Underhill DM, Goodridge HS. Information processing during phagocytosis. Nat Rev Immunol. 2012 Jun 15;12(7):492-502.
- Chawla A, Nguyen KD, Goh YP. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol. 2011 Oct 10;11(11):738-49.
- Chow A, Brown BD, Merad M. Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol. 2011 Oct 25;11(11):788-98.
- Lawrence T, Natoli G. Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol. 2011 Oct 25;11(11):750-61.
- Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011 Oct 14;11(11):723-37.
- Yang Z, Kong B, Mosser DM, Zhang X. TLRs, macrophages, and NK cells: our understandings of their functions in uterus and ovary. Int Immunopharmacol. 2011 Oct;11(10):1442-50.
- Lakshmi Balagopalan, Eilon Sherman, Valarie A. Barr, and Lawrence E. Samelson. Imaging techniques for assaying lymphocyte activation in action. Nat Rev Immunol. 2011 January; 11(1): 21–33.
- Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity. 2010 May 28;32(5):593-604.
- Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol. 2010 Apr;22(2):231-7.
- Nagamatsu T, Schust DJ. The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol. 2010 Jun;63(6):460-71.
- Shakhawat A, Shaikly V, Elzatma E, Mavrakos E, Jabeen A, Fernández N. Interaction between HLA-G and monocyte/macrophages in human pregnancy. J Reprod Immunol. 2010 May;85(1):40-6.
- Coffelt SB, Hughes R, Lewis CE. Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochim Biophys Acta. 2009 Aug;1796(1):11-8.
- Fairweather D, Cihakova D. Alternatively activated macrophages in infection and autoimmunity. J Autoimmun. 2009 Nov-Dec;33(3-4):222-30.
- Helming L, Gordon S. Molecular mediators of macrophage fusion. Trends Cell Biol. 2009 Oct;19(10):514-22.
- O'Brien J, Schedin P. Macrophages in breast cancer: do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer? J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):145-57.
- Pollard JW. Trophic macrophages in development and disease. Nat Rev Immunol. 2009 Apr;9(4):259-70.
- Russell DG, Vanderven BC, Glennie S, Mwandumba H, Heyderman RS. The macrophage marches on its phagosome: dynamic assays of phagosome function. Nat Rev Immunol. 2009 Aug;9(8):594-600.
- Sica A, Allavena P, Mantovani A. Cancer related inflammation: the macrophage connection. Cancer Lett. 2008 Aug 28;267(2):204-15.
- Siveen KS, Kuttan G. Role of macrophages in tumour progression. Immunol Lett. 2009 Apr 27;123(2):97-102.
- Varin A, Gordon S. Alternative activation of macrophages: immune function and cellular biology. Immunobiology. 2009 Jul;214(7):630-41.
- Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008 Dec;8(12):958-69.
- Renaud SJ, Graham CH. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunol Invest. 2008;37(5):535-64.
- Sanguansermsri D, Pongcharoen S. Pregnancy immunology: decidual immune cells. Asian Pac J Allergy Immunol. 2008 Jun-Sep;26(2-3):171-81.
- Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, Rimoldi M, Biswas SK, Allavena P, Mantovani A. Macrophage polarization in tumour progression. Semin Cancer Biol. 2008 Oct;18(5):349-55.
- Bowdish DM, Loffredo MS, Mukhopadhyay S, Mantovani A, Gordon S. Macrophage receptors implicated in the "adaptive" form of innate immunity. Microbes Infect. 2007 Nov-Dec;9(14-15):1680-7.
- Kreider T, Anthony RM, Urban JF Jr, Gause WC. Alternatively activated macrophages in helminth infections. Curr Opin Immunol. 2007 Aug;19(4):448-53.
- Plüddemann A, Neyen C, Gordon S. Macrophage scavenger receptors and host-derived ligands. Methods. 2007 Nov;43(3):207-17.
- Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005 Dec;5(12):953-64.
- Imhof BA, Aurrand-Lions M Adhesion mechanisms regulating the migration of monocytes. Nat Rev Immunol. 2004 Jun;4(6):432-44.
- Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003 Jan;3(1):23-35.
- Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002 Nov;23(11):549-55.
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