IMMUNOLOGIA MOLECOLARE

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IMMUNOLOGIA MOLECOLARE

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MOLECULAR IMMUNOLOGY

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Anno accademico 2013/2014

Codice dell'attività didattica

INT0657

Docente

Prof. Federica CAVALLO (Titolare del corso)

Corso di studi

laurea spec. in biotecnologie molecolari ed Indirizzo Imaging

Anno

1° anno

Periodo didattico

Secondo semestre

Tipologia

Caratterizzante

Crediti/Valenza

SSD dell'attività didattica

MED/04 - patologia generale

Modalità di erogazione

Tradizionale

Lingua di insegnamento

Inglese

Modalità di frequenza

Obbligatoria

Tipologia d'esame

Scritto ed orale

Prerequisiti

Conoscenza dell'Immunologia di base (III Anno - I Livello)

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Obiettivi formativi

To provide an advanced biotechnological up-dating about Macrophages, their receptors, their actions.

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Risultati dell'apprendimento attesi

To teach how to prepare and present a scientific concept.

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Programma

Origin and Morphology of Macrophages: Maturation and function;Chemokines: regulators of development, trafficking and functions; Organ-specific features; Tissue distribution; Education Activation and Programming

Macrophage Subsets: Classically activated Macrophages (M1), Alternatively Activated Macrophages (M2), “Regulatory” Macrophages (IL-10 secretion), Tumor-associated Macrophages (TAMs), Myeloid Derived Suppressor Cells (MDSCs), Lymph node (LN) macrophages, Plasticity and Polarization, Imaging of Macrophages

Function of Macrophages: Phagocytosis: Scavenger Receptors and Toll-like Receptors; Cytokine secretion; Antigen presentation; Homeostatic functions in tissues; Other functions: Iron Trafficking and Metabolism

Functions of Macrophages in Innate Immunity: The phagocytosis process, Role in antimicrobial immunity, Tissue repair

Functions of Macrophages in Adaptive Immunity: Control of T cell proliferation, Interaction with T reg cells, Immunosuppression, Alternative activation of Macrophages

Macrophages and Pregnancy: Monocyte/Macrophages in human pregnancy, Pregnancy Immunology: Decidual Macrophages and their Roles, Role of Macrophages in Utero-placental Interactions

Macrophages and Diseases: Role of macrophages in different diseases, Adipose tissue Macrophages in metabolic disorders, M2 in allergy and asthma, Macrophage subsets and autoimmunity, Macrophages and atherosclerosis, Macrophages in pathogenesis of fibrosis

Macrophages and Tumors: Role of macrophages in tumorigenesis and tumor progression, Macrophages and cancer: balance, tolerance, and diversity, Macrophages in Tumor Microenvironments, Macrophages and Tumor Suppressors

Imaging of Macrophages: Imaging techniques for evaluating cells activation, Tracking immune cells using MRI, Monocytes/Macrophages as nanomedicinal targets

Descrizione

Testi consigliati e bibliografia

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Lawrence T, Natoli G. Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol. 2011 Oct 25;11(11):750-61.
Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011 Oct 14;11(11):723-37.
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Nagamatsu T, Schust DJ. The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol. 2010 Jun;63(6):460-71.
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Renaud SJ, Graham CH. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunol Invest. 2008;37(5):535-64.
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