Corso di Laurea in Biotecnologie

MOLECULAR MEDICINAL CHEMISTRY

Molecular Medicinal Chemistry

Anno accademico 2020/2021

Sommario insegnamento

• Obiettivi formativi
• Risultati dell'apprendimento attesi
• Modalità di insegnamento
• Modalità di verifica dell'apprendimento
• Attività di supporto
• Programma
• Testi consigliati e bibliografia
• Note
• Strumenti didattici

Obiettivi formativi

The main goal of the course is to provide to the students the basis to understand the relationships between the chemical structure of the molecules and their biological activity.

Risultati dell'apprendimento attesi

At the end of the course the student will be able to read critically paper in the field of the drug discovery.

Modalità di insegnamento

The course will be delivered in blended learning.

The 2/3 hour lessons will be held synchronously and will include an introduction to the topic of the day followed by a reading and a discussion of a selected paper.

Lessons will take place in the classroom or in remote presence according to the guidelines provided by the university.

A student is required to attain at least 75% of the attendance for lectures, tutorials and practical sessions of the course (in classroom or in remote presence).

Modalità di verifica dell'apprendimento

Preparation and discussion of infographics on some topics of the course.

Preparation and discussion of a report on topics related to the program of the course.

Exams will be conducted 'face-to-face' or online according to university guidelines.

Attività di supporto

Use of the e-learning platform Moodle

Programma

Drug-Receptor interaction

Basic concepts. Intramolecular interactions. 

Lipophilicity

Basic concepts and definitions. Lipophilicity systems. Methods to measure lipophilicity. 

X-Ray crystallography

Introduction to X-Ray crystallography. Applications to Drug-Discovery.

Cryo Electron Microscopy (Cryo-EM)

Introduction to Cryo-EM. Applications to Drug-Discovery.

Nuclear Magnetic Resonance (NMR)

Basic concepts. Structural determination using NMR. Magnetic Resonance Imaging.

Polarity and Polar Surface Area (PSA)

Definition of polarity and PSA. TPSA. EPSA.

Permeability

Drug transport mechanism through cells. Methods to measure drug-membrane interaction. Methods to measure permeability. Modeling permeability, lipophlicity and polarity.

Solubility

Definitions. Solubility and ADME. Methods for measuring solubility. 

Molecular Dynamics (MD)

Theory of MD. Application of MD to Drug-Discovery.

Binding kinetics

Residence time. Potency and binding kinetics. Binding kinetics in Drug Discovery. Surface Plasmon Resonance (SPR). Isothermal Titration Calorimetry (ITC).

Protein-Protein Interaction (PPI)

Experimental techniques for analysing PPIs. Main databases and repositories. Classifications of PPIs. Hotspots. PPI as a target in Drug Discovery. 

Basic Principles of Drug Discovery and Development
Autore: Benjamin BlassEdizione: 1st
Casa editrice: Academic Press
ISBN: 9780124115088
Url: https://www.elsevier.com/books/basic-principles-of-drug-discovery-and-development/blass/978-0-12-411508-8

The Organic Chemistry of Drug Design and Drug Action
Autore: Richard B. Silverman, Mark W. HollodayEdizione: Third Edition
Casa editrice: Academic Press
ISBN: 9780123820303
Url: https://www.elsevier.com/books/the-organic-chemistry-of-drug-design-and-drug-action/silverman/978-0-12-382030-3

The Practice of Medicinal Chemistry
Autore: Camille Wermuth, David Aldous, Pierre Raboisson, Didier RognanEdizione: Fourth Edition
Casa editrice: Academic Press
ISBN: 9780124172050
Url: https://www.elsevier.com/books/the-practice-of-medicinal-chemistry/wermuth/978-0-12-417205-0

Orario lezioni

Note

“Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico”

• Materiale didattico
• Bacheca appelli
• Vai a Moodle
• Visita i forum