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MOLECULAR MEDICINAL CHEMISTRY
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Molecular Medicinal Chemistry
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Anno accademico 2023/2024
- Codice attività didattica
- BIO0186
- Docente
- Sonja Visentin (Titolare del corso)
- Corso di studio
- Laurea Triennale in Biotecnologie
- Anno
- 3° anno
- Periodo
- Secondo semestre
- Tipologia
- A scelta dello studente
- Crediti/Valenza
- 6
- SSD attività didattica
- CHIM/08 - chimica farmaceutica
- Erogazione
- Mista
- Lingua
- Inglese
- Frequenza
- Obbligatoria
- Tipologia esame
- Scritto ed orale
- Prerequisiti
- Basic knowledge of chemistry and biochemistry.
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Sommario insegnamento
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Obiettivi formativi
What is a drug? This medicinal chemistry course explores how chemists modify a molecule’s structure to design a safe and effective drug.
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Risultati dell'apprendimento attesi
At the end of the course the student will be able to read critically paper in the field of the drug discovery and have a knowledge of the process that a molecule must do to become a drug
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Programma
Pre-Regulatory Medicine and the Drug Approval Process: Modern drug discovery and approval process for the Intellectual property issues with drugs.
Drug pipeline with some example of drugs that changed the life of patients. Drug screening, Filtering hits to find leads Existing drugs and natural products as leads
Drug Targets: Structure of proteins Enzymes and other targets.
Binding, Structure, and Diversity Intermolecular forces.
Molecular diversity and chemical libraries Combinatorial chemistry
Metabolism: Types of metabolic reactions. How can we use metabolism to obtain safe and effective drugs- Oggetto:
Modalità di insegnamento
The course will be delivered in blended learning.
Lessons will take place in the classroom or in remote presence according to the guidelines provided by the university.
A student is required to attain at least 75% of the attendance for lectures, tutorials and practical sessions of the course (in classroom or in remote presence).
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Modalità di verifica dell'apprendimento
Preparation and discussion of infographics on some topics of the course.
Preparation and discussion of a report on topics related to the program of the course.
Exams will be conducted 'face-to-face' or online according to university guidelines.
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Attività di supporto
Use of the e-learning platform Moodle
Testi consigliati e bibliografia
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- Libro
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Basic Principles of Drug Discovery and Development
Autore: Benjamin BlassEdizione: 1st
Casa editrice: Academic Press
ISBN: 9780124115088
Url: https://www.elsevier.com/books/basic-principles-of-drug-discovery-and-development/blass/978-0-12-411508-8The Organic Chemistry of Drug Design and Drug Action
Autore: Richard B. Silverman, Mark W. HollodayEdizione: Third Edition
Casa editrice: Academic Press
ISBN: 9780123820303
Url: https://www.elsevier.com/books/the-organic-chemistry-of-drug-design-and-drug-action/silverman/978-0-12-382030-3The Practice of Medicinal Chemistry
Autore: Camille Wermuth, David Aldous, Pierre Raboisson, Didier RognanEdizione: Fourth Edition
Casa editrice: Academic Press
ISBN: 9780124172050
Url: https://www.elsevier.com/books/the-practice-of-medicinal-chemistry/wermuth/978-0-12-417205-0- Oggetto:
Note
“Le modalità di svolgimento dell'attività didattica potranno subire variazioni in base alle limitazioni imposte dalla crisi sanitaria in corso. In ogni caso è assicurata la modalità a distanza per tutto l'anno accademico”
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Orario lezioni
Lezioni: dal 07/03/2018 al 07/06/2018
Nota: Il corso si svolgerà presso il Dipartimento di Biotecnologie Molecolari e Scienze per la Salute in aula Eraclito.
- Registrazione
- Aperta
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