Prof. Roberto PIVA

Professore/Professoressa associato/a

Contatti

Presso

Curriculum vitae

Pubblicazioni selezionate

Crescenzo R, Abate F, Lasorsa E, Tabbo' F, Gaudiano M, Chiesa N, Di Giacomo F, Spaccarotella E, Barbarossa L, Ercole E, Todaro M, Boi M, Acquaviva A, Ficarra E, Novero D, Rinaldi A, Tousseyn T, Rosenwald A, Kenner L, Cerroni L, Tzankov A, Ponzoni M, Paulli M, Weisenburger D, Chan WC, Iqbal J, Piris MA, Zamo' A, Ciardullo C, Rossi D, Gaidano G, Pileri S, Tiacci E, Falini B, Shultz LD, Mevellec L, Vialard JE, Piva R, Bertoni F, Rabadan R, Inghirami G. (2015) Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Cancer cell 27(4) 516-32 [DOI  PMID]

Abate F, Todaro M, van der Krogt JA, Boi M, Landra I, Machiorlatti R, Tabbo F, Messana K, Abele C, Barreca A, Novero D, Gaudiano M, Aliberti S, Di Giacomo F, Tousseyn T, Lasorsa E, Crescenzo R, Bessone L, Ficarra E, Acquaviva A, Rinaldi A, Ponzoni M, Longo DL, Aime S, Cheng M, Ruggeri B, Piccaluga PP, Pileri S, Tiacci E, Falini B, Pera-Gresely B, Cerchietti L, Iqbal J, Chan WC, Shultz LD, Kwee I, Piva R, Wlodarska I, Rabadan R, Bertoni F, Inghirami G. (2015) A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation. Leukemia 29(6) 1390-401 [DOI  PMID]

Piva R, Deaglio S, Fama R, Buonincontri R, Scarfo I, Bruscaggin A, Mereu E, Serra S, Spina V, Brusa D, Garaffo G, Monti S, Dal Bo M, Marasca R, Arcaini L, Neri A, Gattei V, Paulli M, Tiacci E, Bertoni F, Pileri SA, Foa R, Inghirami G, Gaidano G, Rossi D. (2015) The Kruppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma. Leukemia 29(2) 503-7 [DOI  PMID]

Martinengo C, Poggio T, Menotti M, Scalzo MS, Mastini C, Ambrogio C, Pellegrino E, Riera L, Piva R, Ribatti D, Pastorino F, Perri P, Ponzoni M, Wang Q, Voena C, Chiarle R. (2014) ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis. Cancer research 74(21) 6094-106 [DOI  PMID]

Sapienza MR, Fuligni F, Agostinelli C, Tripodo C, Righi S, Laginestra MA, Pileri A Jr, Mancini M, Rossi M, Ricci F, Gazzola A, Melle F, Mannu C, Ulbar F, Arpinati M, Paulli M, Maeda T, Gibellini D, Pagano L, Pimpinelli N, Santucci M, Cerroni L, Croce CM, Facchetti F, Piccaluga PP, Pileri SA. (2014) Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition. Leukemia 28(8) 1606-16 [DOI  PMID]

Verdelli D, Nobili L, Todoerti K, Mosca L, Fabris S, D'Anca M, Pellegrino E, Piva R, Inghirami G, Capelli C, Introna M, Baldini L, Chiaramonte R, Lombardi L, Neri A. (2014) Molecular events underlying interleukin-6 independence in a subclone of the CMA-03 multiple myeloma cell line. Genes, chromosomes & cancer 53(2) 154-67 [DOI  PMID]

Saoncella S, Tassone B, Deklic E, Avolio F, Jon C, Tornillo G, De Luca E, Di Iorio E, Piva R, Cabodi S, Turco E, Pandolfi PP, Calautti E. (2014) Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway. Stem cells (Dayton, Ohio) 32(3) 754-69 [DOI  PMID]

Abate F, Acquaviva A, Ficarra E, Piva R, Macii E. (2013) Gelsius: a literature-based workflow for determining quantitative associations between genes and biological processes. IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM 10(3) 619-31 [DOI  PMID]

Boi M, Rinaldi A, Kwee I, Bonetti P, Todaro M, Tabbo F, Piva R, Rancoita PM, Matolcsy A, Timar B, Tousseyn T, Rodriguez-Pinilla SM, Piris MA, Bea S, Campo E, Bhagat G, Swerdlow SH, Rosenwald A, Ponzoni M, Young KH, Piccaluga PP, Dummer R, Pileri S, Zucca E, Inghirami G, Bertoni F. (2013) PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. Blood 122(15) 2683-93 [DOI  PMID]

Spaccarotella E, Pellegrino E, Ferracin M, Ferreri C, Cuccuru G, Liu C, Iqbal J, Cantarella D, Taulli R, Provero P, Di Cunto F, Medico E, Negrini M, Chan WC, Inghirami G, Piva R. (2014) STAT3-mediated activation of microRNA cluster 17~92 promotes proliferation and survival of ALK-positive anaplastic large cell lymphoma. Haematologica 99(1) 116-24 [DOI  PMID]

Bonetti P, Testoni M, Scandurra M, Ponzoni M, Piva R, Mensah AA, Rinaldi A, Kwee I, Tibiletti MG, Iqbal J, Greiner TC, Chan WC, Gaidano G, Piris MA, Cavalli F, Zucca E, Inghirami G, Bertoni F. (2013) Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma. Blood 122(13) 2233-41 [DOI  PMID]

Peviani M, Tortarolo M, Battaglia E, Piva R, Bendotti C. (2014) Specific induction of Akt3 in spinal cord motor neurons is neuroprotective in a mouse model of familial amyotrophic lateral sclerosis. Molecular neurobiology 49(1) 136-48 [DOI  PMID]

Piccaluga PP, Fuligni F, De Leo A, Bertuzzi C, Rossi M, Bacci F, Sabattini E, Agostinelli C, Gazzola A, Laginestra MA, Mannu C, Sapienza MR, Hartmann S, Hansmann ML, Piva R, Iqbal J, Chan JC, Weisenburger D, Vose JM, Bellei M, Federico M, Inghirami G, Zinzani PL, Pileri SA. (2013) Molecular profiling improves classification and prognostication of nodal peripheral T-cell lymphomas: results of a phase III diagnostic accuracy study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31(24) 3019-25 [DOI  PMID]

Liu C, Iqbal J, Teruya-Feldstein J, Shen Y, Dabrowska MJ, Dybkaer K, Lim MS, Piva R, Barreca A, Pellegrino E, Spaccarotella E, Lachel CM, Kucuk C, Jiang CS, Hu X, Bhagavathi S, Greiner TC, Weisenburger DD, Aoun P, Perkins SL, McKeithan TW, Inghirami G, Chan WC. (2013) MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma. Blood 122(12) 2083-92 [DOI  PMID]

Tabbo F, Ponzoni M, Rabadan R, Bertoni F, Inghirami G. (2013) Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma. Current opinion in hematology 20(4) 374-81 [DOI  PMID]

Abate F, Acquaviva A, Ficarra E, Piva R, Macii E. (2013) Gelsius: A Literature-Based Workflow for Determining Quantitative Associations Between Genes and Biological Processes. IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM [DOI  PMID]

Laimer D, Dolznig H, Kollmann K, Vesely PW, Schlederer M, Merkel O, Schiefer AI, Hassler MR, Heider S, Amenitsch L, Thallinger C, Staber PB, Simonitsch-Klupp I, Artaker M, Lagger S, Turner SD, Pileri S, Piccaluga PP, Valent P, Messana K, Landra I, Weichhart T, Knapp S, Shehata M, Todaro M, Sexl V, Hofler G, Piva R, Medico E, Ruggeri BA, Cheng M, Eferl R, Egger G, Penninger JM, Jaeger U, Moriggl R, Inghirami G, Kenner L. (2012) PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nature medicine 18(11) 1699-704 [DOI  PMID]

Agnelli L, Mereu E, Pellegrino E, Limongi T, Kwee I, Bergaggio E, Ponzoni M, Zamo A, Iqbal J, Piccaluga PP, Neri A, Chan WC, Pileri S, Bertoni F, Inghirami G, Piva R. (2012) Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma. Blood 120(6) 1274-81 [DOI  PMID]

Tabbo F, Barreca A, Piva R, Inghirami G. (2012) ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma. Frontiers in oncology 2 41 [DOI  PMID]

Peviani M, Kurosaki M, Terao M, Lidonnici D, Gensano F, Battaglia E, Tortarolo M, Piva R, Bendotti C. (2012) Lentiviral vectors carrying enhancer elements of Hb9 promoter drive selective transgene expression in mouse spinal cord motor neurons. Journal of neuroscience methods 205(1) 139-47 [DOI  PMID]

Kwee I, Rinaldi A, Rancoita P, Rossi D, Capello D, Forconi F, Giuliani N, Piva R, Inghirami G, Gaidano G, Zucca E, Bertoni F. (2012) Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array. British journal of haematology 156(3) 354-7 [DOI  PMID]

Inghirami G, Pileri SA. (2011) Anaplastic large-cell lymphoma. Seminars in diagnostic pathology 28(3) 190-201 [PMID]

Barreca A, Lasorsa E, Riera L, Machiorlatti R, Piva R, Ponzoni M, Kwee I, Bertoni F, Piccaluga PP, Pileri SA, Inghirami G. (2011) Anaplastic lymphoma kinase in human cancer. Journal of molecular endocrinology 47(1) R11-23 [DOI  PMID]

Piccaluga PP, Gazzola A, Mannu C, Agostinelli C, Bacci F, Sabattini E, Sagramoso C, Piva R, Roncolato F, Inghirami G, Pileri SA. (2010) Pathobiology of anaplastic large cell lymphoma. Advances in hematology 345053 [DOI  PMID]

Piva R, Agnelli L, Pellegrino E, Todoerti K, Grosso V, Tamagno I, Fornari A, Martinoglio B, Medico E, Zamo A, Facchetti F, Ponzoni M, Geissinger E, Rosenwald A, Muller-Hermelink HK, De Wolf-Peeters C, Piccaluga PP, Pileri S, Neri A, Inghirami G. (2010) Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 28(9) 1583-90 [DOI  PMID]

Belardo G, Piva R, Santoro MG. (2010) Heat stress triggers apoptosis by impairing NF-kappaB survival signaling in malignant B cells. Leukemia 24(1) 187-96 [DOI  PMID]

Regis G, Icardi L, Conti L, Chiarle R, Piva R, Giovarelli M, Poli V, Novelli F. (2009) IL-6, but not IFN-gamma, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing. Leukemia 23(11) 2102-8 [DOI  PMID]

Fornari A, Piva R, Chiarle R, Novero D, Inghirami G. (2009) Anaplastic large cell lymphoma: one or more entities among T-cell lymphoma? Hematological oncology 27(4) 161-70 [DOI  PMID]

Chiarle R, Voena C, Ambrogio C, Piva R, Inghirami G. (2008) The anaplastic lymphoma kinase in the pathogenesis of cancer. Nature reviews. Cancer 8(1) 11-23 [DOI  PMID]

Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC. (2008) Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. Journal of leukocyte biology 83(3) 648-62 [DOI  PMID]

Piva R, Ruggeri B, Williams M, Costa G, Tamagno I, Ferrero D, Giai V, Coscia M, Peola S, Massaia M, Pezzoni G, Allievi C, Pescalli N, Cassin M, di Giovine S, Nicoli P, de Feudis P, Strepponi I, Roato I, Ferracini R, Bussolati B, Camussi G, Jones-Bolin S, Hunter K, Zhao H, Neri A, Palumbo A, Berkers C, Ovaa H, Bernareggi A, Inghirami G. (2008) CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood 111(5) 2765-75 [DOI  PMID]

Piva R, Pellegrino E, Inghirami G. (2007) Identification and validation of the anaplastic large cell lymphoma signature. Advances in experimental medicine and biology 604 129-36 [DOI  PMID]

Di Stefano P, Damiano L, Cabodi S, Aramu S, Tordella L, Praduroux A, Piva R, Cavallo F, Forni G, Silengo L, Tarone G, Turco E, Defilippi P. (2007) p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. The EMBO journal 26(12) 2843-55 [DOI  PMID]

Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F. (2007) Essential role of PDK1 in regulating endothelial cell migration. The Journal of cell biology 176(7) 1035-47 [DOI  PMID]

Piva R, Pellegrino E, Mattioli M, Agnelli L, Lombardi L, Boccalatte F, Costa G, Ruggeri BA, Cheng M, Chiarle R, Palestro G, Neri A, Inghirami G. (2006) Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes. The Journal of clinical investigation 116(12) 3171-82 [DOI  PMID]

Ciucci A, Gianferretti P, Piva R, Guyot T, Snape TJ, Roberts SM, Santoro MG. (2006) Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. Molecular pharmacology 70(5) 1812-21 [DOI  PMID]

Piva R, Belardo G, Santoro MG. (2006) NF-kappaB: a stress-regulated switch for cell survival. Antioxidants & redox signaling 8(3-4) 478-86 [DOI  PMID]

Piva R, Chiarle R, Manazza AD, Taulli R, Simmons W, Ambrogio C, D'Escamard V, Pellegrino E, Ponzetto C, Palestro G, Inghirami G. (2006) Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. Blood 107(2) 689-97 [DOI  PMID]

Ambrogio C, Voena C, Manazza AD, Piva R, Riera L, Barberis L, Costa C, Tarone G, Defilippi P, Hirsch E, Boeri Erba E, Mohammed S, Jensen ON, Palestro G, Inghirami G, Chiarle R. (2005) p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood 106(12) 3907-16 [DOI  PMID]

Inghirami G, Chiarle R, Simmons WJ, Piva R, Schlessinger K, Levy DE. (2005) New and old functions of STAT3: a pivotal target for individualized treatment of cancer. Cell cycle (Georgetown, Tex.) 4(9) 1131-3 [PMID]

Piva R, Gianferretti P, Ciucci A, Taulli R, Belardo G, Santoro MG. (2005) 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. Blood 105(4) 1750-8 [DOI  PMID]

Bendotti C, Atzori C, Piva R, Tortarolo M, Strong MJ, DeBiasi S, Migheli A. (2004) Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice. Journal of neuropathology and experimental neurology 63(2) 113-9 [PMID]

Chiarle R, Gong JZ, Guasparri I, Pesci A, Cai J, Liu J, Simmons WJ, Dhall G, Howes J, Piva R, Inghirami G. (2003) NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. Blood 101(5) 1919-27 [DOI  PMID]

Piva R, Liu J, Chiarle R, Podda A, Pagano M, Inghirami G. (2002) In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation. Molecular and cellular biology 22(23) 8375-87 [PMID]

Schiffer D, Cavalla P, Fiano V, Ghimenti C, Piva R. (2002) Inverse relationship between p27/Kip.1 and the F-box protein Skp2 in human astrocytic gliomas by immunohistochemistry and Western blot. Neuroscience letters 328(2) 125-8 [PMID]

Chiarle R, Fan Y, Piva R, Boggino H, Skolnik J, Novero D, Palestro G, De Wolf-Peeters C, Chilosi M, Pagano M, Inghirami G. (2002) S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase. The American journal of pathology 160(4) 1457-66 [DOI  PMID]

Zamo A, Chiarle R, Piva R, Howes J, Fan Y, Chilosi M, Levy DE, Inghirami G. (2002) Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene 21(7) 1038-47 [DOI  PMID]

Atzori C, Ghetti B, Piva R, Srinivasan AN, Zolo P, Delisle MB, Mirra SS, Migheli A. (2001) Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. Journal of neuropathology and experimental neurology 60(12) 1190-7 [PMID]

Audero E, Cascone I, Zanon I, Previtali SC, Piva R, Schiffer D, Bussolino F. (2001) Expression of angiopoietin-1 in human glioblastomas regulates tumor-induced angiogenesis: in vivo and in vitro studies. Arteriosclerosis, thrombosis, and vascular biology 21(4) 536-41 [PMID]

Chilosi M, Chiarle R, Lestani M, Menestrina F, Montagna L, Ambrosetti A, Prolla G, Pizzolo G, Doglioni C, Piva R, Pagano M, Inghirami G. (2000) Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia. British journal of haematology 111(1) 263-71 [PMID]

Migheli A, Mongini T, Doriguzzi C, Chiado-Piat L, Piva R, Ugo I, Palmucci L. (1997) Muscle apoptosis in humans occurs in normal and denervated muscle, but not in myotonic dystrophy, dystrophinopathies or inflammatory disease. Neurogenetics 1(2) 81-7 [PMID]

Cavalla P, Piva R, Bortolotto S, Grosso R, Cancelli I, Chio A, Schiffer D. (1999) p27/kip1 expression in oligodendrogliomas and its possible prognostic role. Acta neuropathologica 98(6) 629-34 [PMID]

Migheli A, Atzori C, Piva R, Tortarolo M, Girelli M, Schiffer D, Bendotti C. (1999) Lack of apoptosis in mice with ALS. Nature medicine 5(9) 966-7 [DOI  PMID]

Migheli A, Piva R, Casolino S, Atzori C, Dlouhy SR, Ghetti B. (1999) A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum. The American journal of pathology 155(2) 365-73 [DOI  PMID]

Piva R, Cancelli I, Cavalla P, Bortolotto S, Dominguez J, Draetta GF, Schiffer D. (1999) Proteasome-dependent degradation of p27/kip1 in gliomas. Journal of neuropathology and experimental neurology 58(7) 691-6 [PMID]

Schiffer D, Bortolotto S, Bosone I, Cancelli I, Cavalla P, Schiffer P, Piva R. (1999) Cell-cycle inhibitor p27/Kip-1 expression in non-astrocytic and non-oligodendrocytic human nervous system tumors. Neuroscience letters 264(1-3) 29-32 [PMID]

Migheli A, Cordera S, Bendotti C, Atzori C, Piva R, Schiffer D. (1999) S-100beta protein is upregulated in astrocytes and motor neurons in the spinal cord of patients with amyotrophic lateral sclerosis. Neuroscience letters 261(1-2) 25-8 [PMID]

Wei J, Hodes ME, Piva R, Feng Y, Wang Y, Ghetti B, Dlouhy SR. (1998) Characterization of murine Girk2 transcript isoforms: structure and differential expression. Genomics 51(3) 379-90 [DOI  PMID]

Cavalla P, Dutto A, Piva R, Richiardi P, Grosso R, Schiffer D. (1998) Cyclin D1 expression in gliomas. Acta neuropathologica 95(2) 131-5 [PMID]

Piva R, Cavalla P, Bortolotto S, Cordera S, Grosso R, Richiardi P, Dutto A, Schiffer D. (1998) CDKN2/p16 inactivation and p16 immunohistochemistry in astrocytic gliomas. International journal of oncology 12(1) 55-8 [PMID]

Migheli A, Piva R, Atzori C, Troost D, Schiffer D. (1997) c-Jun, JNK/SAPK kinases and transcription factor NF-kappa B are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis. Journal of neuropathology and experimental neurology 56(12) 1314-22 [PMID]

Migheli A, Piva R, Wei J, Attanasio A, Casolino S, Hodes ME, Dlouhy SR, Bayer SA, Ghetti B. (1997) Diverse cell death pathways result from a single missense mutation in weaver mouse. The American journal of pathology 151(6) 1629-38 [PMID]

Piva R, Cavalla P, Bortolotto S, Cordera S, Richiardi P, Schiffer D. (1997) p27/kip1 expression in human astrocytic gliomas. Neuroscience letters 234(2-3) 127-30 [PMID]

Schiffer D, Dutto A, Cavalla P, Chio A, Migheli A, Piva R. (1997) Role of apoptosis in the prognosis of oligodendrogliomas. Neurochemistry international 31(2) 245-50 [PMID]

Wei J, Dlouhy SR, Bayer S, Piva R, Verina T, Wang Y, Feng Y, Dupree B, Hodes ME, Ghetti B. (1997) In situ hybridization analysis of Girk2 expression in the developing central nervous system in normal and weaver mice. Journal of neuropathology and experimental neurology 56(7) 762-71 [PMID]

Migheli A, Cavalla P, Piva R, Giordana MT, Schiffer D. (1994) bcl-2 protein expression in aged brain and neurodegenerative diseases. Neuroreport 5(15) 1906-8 [PMID]

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