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IMMUNOLOGIA MOLECOLARE
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MOLECULAR IMMUNOLOGY
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Anno accademico 2014/2015
- Codice dell'attività didattica
- INT0657
- Docente
- Prof. Federica CAVALLO (Titolare del corso)
- Corso di studi
- laurea spec. in biotecnologie molecolari ed Indirizzo Imaging
- Anno
- 1° anno
- Periodo didattico
- Secondo semestre
- Tipologia
- Caratterizzante
- Crediti/Valenza
- 5
- SSD dell'attività didattica
- MED/04 - patologia generale
- Modalità di erogazione
- Tradizionale
- Lingua di insegnamento
- Inglese
- Modalità di frequenza
- Obbligatoria
- Tipologia d'esame
- Scritto ed orale
- Prerequisiti
- Conoscenza dell'Immunologia di base (III Anno - I Livello)
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Sommario insegnamento
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Obiettivi formativi
To provide an advanced biotechnological up-dating about Germinal Center its functions.- Oggetto:
Risultati dell'apprendimento attesi
To teach how to prepare and present a scientific concept.- Oggetto:
Modalità di insegnamento
How the course is organized:
A.The students are supposed to prepare a 20 min presentation about some aspects of Germinal Center immune response using the supplied bibliography;
B.The students are supposed to interact and discuss the various presentations during the lessons; if they miss some lessons, these topics will be discussed during the exam section.
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Modalità di verifica dell'apprendimento
What the student is supposed to do:
1. Study the topic and choose the relevant information;
2. Prepare the presentation in powerpoint;
3. Present the data;
4. Participate in the debate during the lesson;
5. Answer the three easy questions given at the end of the lesson in a few lines (they will contribute to final mark).
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Programma
B cells: Origin, morphology and functions of B cells; Structure of antibodies and their biological function; Classes of immunoglobulins; The Fc region and the Fc Receptor (FcR).
B Follicular Cells: T cell dependent immune response; three major classes of B antigens: T-dependent antigens (TDs), T-independent antigens (TI-1 and TI-2); cognate and non-cognate signals.
T cells and Memory T Cell: Origin, morphology and functions of T cells; Education, activation and programming; Chemokines: regulators of development, trafficking and functions.
T Follicular Cells: The T cells subsets (Th1, Th2, Th9, Th17, Th22, Treg, Tr1, Tgd, NKT); T follicular helper cells: differentiation and functions; Role of TFH cells in health and disease.
Somatic Hypermutation: Role of activation-induced cytidine deaminase enzyme (AID); CD40L-CD40 interactions; Affinity maturation.
Class Switching: The switch recombination and AID enzyme; the importance of switch regions; the cytokines that influence the isotype switching; subsets of antibodies.
Memory B Cells and Plasma cells: Memory B cells: general characteristics; activation of B cells in secondary responses; mechanism of antibody synthesis; short-lived plasma cells (Bcl-6); long-lived plasma cells (IL-2 and IL-10).
Follicular Dendritic Cells: The antigen-antibody complexes (immune complexes); the antigen-antibody-complement complexes; Esosomes and Iccosomes.
The Germinal Center Reaction: dark zone, light zone and mantle zone; the tingible body macrophages; the functions of high endothelial venules (HEV); centroblasts and centocytes; lymphocyte trafficking.
Germinal Center in Diseases: B cell-Specific Primary Immunodeficiencies (B-Pls); Hyper IgM (HIGM) Syndromes; Lymphomas and myelomas.
Germinal Center and Imaging: Imaging techniques for evaluating cells activation; Tracking immune cells using MRI; new germinal center visions from in vivo imaging.
Testi consigliati e bibliografia
- Oggetto:
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